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These metabolites can be broadly classified into water-soluble antioxidantssuch as proline, glycine betaine, ascorbic acid (AsA), and glutathione (GSH)and lipophilic antioxidants, including tocopherols and carotenoids, reflecting both their chemical properties and intracellular compartmentalization (Mishra et al

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Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha