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The high level of health complications among study patients may exacerbate the risk of known negative health outcomes, including poor glycemic control [28], hypoglycemic events [29, 30], syncope [30], poor quality of life [31, 32], need for inpatient care [30], and death [30, 33], highlighting that more effective T2DM treatments, not just more treatments, are needed

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Methylation requires a special form of folate known as 5-methyltetrahydrofolate (5-MTHF)

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