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The primary outcomes were changes in body mass index (BMI), body weight, waist circumference (WC), waist-to-hip ratio (WHR) and abdominal girth (AG)

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HALLMARK gene set enrichment analysis (GSEA) identified suppression of Estrogen Response genes, E2F targets and other proliferation-associated gene sets as being suppressed by giredestrant, consistent with its anticipated effects as an ER antagonist (Supplementary Fig

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