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There could be many reasons for it, such as: Genetics resulting in producing less DAO High requirements for DAO due to a diet high in histamines or foods (or medications) that trigger histamine release Excessive release of histamines in the body due to an immune response Intake of substances that block DAO such as alcohol Decreased production of DAO due to poor gut health or aging If there is a deficiency of DAO in relationship to the amount of histamines that need to be cleared, taking a DAO supplement (Histamine Digest) can support the clearing of histamines from foods, or from foods (and medicines) that trigger the release of histamines