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This work is what separates people who maintain their results from people who regain

47% of people (5 in 10) lost at least 15%

Glycaemic efficacy Compared with placebo, tirzepatide 15 mg was the most efficacious treatment in reducing HbA 1c (MD [95% CI]: 21.61 mmol/mol [23.26 to 19.97] [1.96% (2.11 to 1.82)]), followed by tirzepatide 10 mg (20.19 mmol/mol [21.89 to 18.48] [1.84% (1.99 to 1.69)]), semaglutide 2.0 mg (17.74 mmol/mol [22.03 to 13.45] [1.59% (1.95 to 1.22)]), tirzepatide 5 mg (17.60 mmol/mol [19.36 to 15.84] [1.60% (1.75 to 1.44)]), semaglutide 1.0 mg (15.25 mmol/mol [16.73 to 13.77] [1.39% (1.52 to 1.26)]) and semaglutide 0.5 mg (12.00 mmol/mol [13.74 to 10.26] [1.09% (1.24 to 0.94)]) (Fig

Most providers recommend continuing the pyridoxine formulation at least through the full dose escalation phase (approximately 16-20 weeks)

doi: 10.1001/jama.2013.285063