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[Figure 1] Schematic drawing of the Blood-brain Barrier

There is accumulating evidence for diverse changes in molecular expression of reactive astrocytes in different types and different severities of tissue pathology, 62,65,68,69 but there is not yet a good synthesis of how molecular, metabolic, 87 structural, and functional changes relate to one another to generate precisely definable phenotypes

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Specifically, 32% struggled to fall asleep, and 16% experienced moderate insomnia