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Researchers estimate that more than 137 million U.S
Examples of drugs that are in the latter class include the anti-malarial drugs dapsone and primaquine, as well as rasburicase which is normally used in the treatment tumor lysis syndrome in patients undergoing chemotherapy for hematologic cancers, but has also been used to reduce the hyperuricemia associated with gout
It is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and it is not recommended in pregnancy or breastfeeding without provider direction
In SURMOUNT-2, SURMOUNT-3 and SURMOUNT-4 were used TZP doses of 10 and 15 mg and all three doses, including the 5-mg dose, were used in SURMOUNT-1
Data from over 60 million patients treated in over 2,000 general practices were obtained from the United Kingdom Clinical Practice Research Datalink (CPRD) GOLD and Aurum
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