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Efficacy of Once-Weekly Semaglutide versus Placebo as Add-on to Insulin in Subjects with Type 2 Diabetes (SUSTAIN 5): A Randomized, Double-Blind, Placebo-Controlled, Phase 3a Trial

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Semaglutide works by mimicking a hormone called GLP-1, which: Slows down digestion through a process called gastric emptying, which helps prolong satiety and reduces food cravings Reduces appetite Increases feelings of fullness Regulates blood sugar These effects help patients eat less by increasing feelings of fullness and causing a reduced appetite, making it easier to avoid cravings and lose weight more consistently over time

Neurochemical Research 32.4 (2007): 757-773