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Although they signed consent forms agreeing to take the drug, they were reportedly not aware that its effects were being tested

TB-500 is a synthetic version of the active region of thymosin beta-4, a protein found in nearly every cell in the mammalian body

Springer J, Scholz FR, Peiser C, Groneberg D, Fischer A: SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke

In addition, researchers have found that the aging of cartilage is not caused by telomere wear and aging of mature chondrocytes, but is attributed to a group of progenitor cells (Fellows et al., 2017)