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In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

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Niacinamide (10%) Blocks melanin transfer to skin cells the final step causing visible pigmentation

Liu, C., Zhang, F., Munske, G., Zhang, H

If you notice new, spreading, or unexplained white patches, consult a dermatologist.