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While several groups have demonstrated the superiority of natively paired libraries in generating high affinity and high potency antibodies 16,17,18,19 , the role that maintaining cognate chain pairing plays on an antibodys developability profile has been largely unexplored

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One strategy some research users report is maintaining a lower maintenance dose rather than stopping entirely, similar to how the clinical trial community is now discussing long-term low-dose maintenance for GLP-1 class medications broadly

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