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For this reason, most providers recommend erring on the side of caution

This is not a true detoxification process as the dihydrodiol product can rearrange at neutral pH values to form a dialdehydic phenolate ion

Risk factors that might warrant consideration of medication adjustment include: Recent initiation or dose escalation of GLP-1 therapy Significant gastrointestinal symptoms (nausea, vomiting, early satiety) Maximum medication doses Known gastroparesis or other conditions affecting gastric emptying For patients where holding the medication is deemed appropriate, the duration should be individualized based on the specific medication, patient factors, and clinical judgment

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