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The mechanism appears to involve insulin resistance at the L-cell itself

(500 mg/kg) and reductions of 50 % and 17% at 21 and 28 d.p.i

2.6.1.1.2 Inhibitors of enzymes of fatty acid metabolism In some types of cancer acyl-CoA:cholesterol acyltransferase (ACAT)1 inhibitors such as nevanimibe and K-604 have been shown to reduce tumor progression and enhance TIL functions by downregulating cholesterol synthesis and energy production in tumor cells while enhancing FAO and OXPHOS in T cells ( Figure 1B2 ) ( Inhibitors of another enzyme of lipid metabolism

doi: 10.3389/fimmu.2023.1080310 23 CaputoTGilardiFDesvergneB

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