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However, more significant reductions in HbA1c levels (average blood sugar levels over the previous 2-3 months) usually develop over about 8-12 weeks of continued treatment

Miao C, Wang X, Zhou W, Huang J

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For determination of GLUT2 (Glucose transporter 2) and GLP-1R (glucagon-like peptide 1 receptor) concentrations in pancreas and liver, tissues were rinsed in ice-cold PBS (0.01 mol.L 1 , pH 7.07.2) to remove excess blood thoroughly and weighed before homogenization