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In Fmr1 -KO mice, in which pharmacological intervention with PD158780 (ErbB inhibitor) led to a reduction in repetitive behaviors, electrophysiological experiments showed that the behavioral effects were due to a reduction in mGluR1/5-activated currents (I DHPG ) and the co-occurrence of spontaneous firing hyperactivity and hyperexcitability of SNpc DA neurons [57]
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Recently, the bacterial IMPDH, GuaB (inosine-5-monophosphate dehydrogenase) enzyme, a compound of the purine nucleotide biosynthetic pathway, has become popular as a potential target for eradication multi-drug resistant pathogens such as Cryptosporidium parvum or Mycobacterium tuberculosis
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