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In this context, postbiotics are more plausibly positioned not as primary weight-loss interventions, but as nutritional strategies that may be continued after GLP-1based pharmacotherapy to support metabolic stability, mitigate weight regain, and preserve lean mass during the post-treatment phase ( From a clinical nutrition perspective, postbiotics should not be positioned as weight-loss agents, nor as substitutes for pharmacological GLP-1 receptor agonists

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According to Murphy et al., animals fed HFD had a decrease in Bacteroidetes and an increase in Firmicutes and Proteobacteria, the latter two being common pathogens (95)

J Am Coll Cardiol 48(8):15271537

NAD+ is an oxidizing agent that helps support the aging processes, improve stress resistance, and promote DNA repair