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Exploring whether the triple-agonist approach produces additive or synergistic effects beyond what dual-receptor compounds alone can achieve

In one study, the chemotherapy agent doxorubicin caused twice the tumor growth inhibition in mice given a green tea beverage compared with those that did not receive green tea

It's important to note that feeling cold is not listed as an official side effect in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), and evidence for this effect is largely anecdotal from patient reports and clinical observations

Cha H, Kim M, Ahn N, Jeong SD, Ignatova E, Chi SW, et al

In rats, the oral dose found to be effective was 10g/kg, or 1.6g/kg