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Important issues to review include nausea, vomiting, constipation, diarrhea, reflux, hydration status, protein intake, muscle preservation, diabetes medications, gallbladder symptoms, kidney function, history of pancreatitis, thyroid and family history considerations, and long-term maintenance strategy

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Emerging research on melanocortin-4 receptor (MC4R) agonists combined with GLP-1/GIP agonists has shown promise for enhanced weight loss and prevention of weight regain, potentially addressing the needs of patients who plateau on current monotherapy [53]

(2) RCTs completed before the FDA guidance of 2008 [17] and (3) follow-up duration of at least 6 months