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Dihydroorotate dehydrogenase (DHODH) within mitochondria is believed to help maintain redox balance in this organelle ( 2.3 Experimental evidence for ferroptosis in OA In recent years, as our understanding of ferroptosis has deepened, numerous basic and preclinical studies have accumulated compelling evidence supporting its active role in OA pathology

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We still cant draw strong conclusions from two case reports, but the pattern is worth noting for a population that already tends to have issues with muscle function and fatigue