Similar to the lymphocytic thyroid infiltration observed in hypertension, histopathological examinations demonstrate lymphocytic infiltration and loss of melanocytes in lesional skin, suggesting comparable immunopathogenic pathways
In addition, there is the problem of concomitancy, based on molecular mimicry, whereby certain foods cross-react against specific pollens
Therefore, increased ROS/RNS levels induced by several clinical conditions may play a deleterious effect on different biomolecules (e.g., lipids, proteins and nucleic acids), organelles and antioxidant defenses, leading to exacerbate nitro-oxidative stress, mitochondrial dysfunction, glial activation and inflammatory response
Three properties drive it: 1
Such manifestations significantly impair quality of life, often associated with psychological comorbidities such as anxiety and depression [78]