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In the STEP 1 trial, once weekly GLP-1 agonist at 2.4 mg with lifestyle intervention led to a mean body weight reduction of 14.9 percent at 68 weeks, compared with 2.4 percent with placebo 2
And when paired with reduced food intake, less overall fiber, and a dramatic shift in eating habits, it can lead to significant constipation
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It stimulates collagen I and III synthesis, promotes decorin production (which regulates collagen fibril assembly), increases angiogenesis, and has anti-inflammatory effects through suppression of TGF-beta
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