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Future clinical trials evaluating Gln catabolism in human immune cell responses will be useful in determining its function in autoimmune diseases and may be a potential target for the treatment of autoimmune diseases

Exp Hematol 104:916 Dulmovits BM, Hom J, Narla A, Mohandas N, Blanc L (2017) Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis

Human metabolism relies heavily on the gut microbiome to assure an abundant supply of deuterium depleted (deupleted) nutrients to the host

doi: 10.1002/acr.22900 55 ArmahHBWangGOmaluBITeshRBGyureKAChuteDJet al

However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]