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10.1016/j.tox.2022.153297 116 LiuZ.WangW.LiX.TangS.MengD.XiaW.et al (2022d)

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, such as through MT1 or MT2 or other receptors/regulatory proteins, changes induced by melatonin or its metabolites in mitochondrial activity that affect the activity of ROR, and indirectly affecting the activity of the nuclear receptor, REV-ERB, which also interacts with the RORE, thus influencing the expression of the same target genes as the ROR [25]