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Proc Nutr Soc 59:537540 Ghio AJ, Piantadosi CA, Crumbliss AL (1997) Hypothesis: iron chelation plays a vital role in neutrophilic inflammation

A multisystem approach to diagnosis and treatment is indicated

According to hormesis, low doses of food nutrients are neuroprotective by activating Nrf2 antioxidant pathways, while high doses can be toxic and induce inhibition of these protective pathways, causing brain damage

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After being stimulated, neurons of the paraventricular nucleus of the hypothalamus release corticotropin-releasing hormone (CRH), which will be transported by hypothalamic-pituitary portal circulation and stimulate pituitary corticotroph cells to cleave proopiomelanocortin (POMC) in adrenocorticotrophic hormone (ACTH) [12]