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The aromatase encoded by the CYP19A1 gene is a key rate limiting enzyme in the estradiol (E2) synthesis pathway

The current European Union (EU) recommended daily intake is 1.5 micrograms for infants and children under six, 2.5 micrograms for seven to 10-year-olds, 3.5 micrograms for 11 to 14-year-olds, four micrograms for everyone over 15, increasing to 4.5 micrograms during pregnancy and five micrograms for breastfeeding women (EFSA, 2015)

Studies show conflicting results on whether having a higher body weight can affect the course of UC

There are some fortified plant-based options for getting B12, but for the most part, you may find this important vitamin in animal-based products