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By design, MB affects redox status in red blood cells, and if misused, it can actually cause or worsen methemoglobinemia (particularly if overdosed) or precipitate hemolysis in G6PD-deficient patients

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The inhibition of ATG5, a mediator of autophagy in hypoxic cancer, can induce cisplatin sensitivity in previously resistant cells (188), supporting the contribution of hypoxia-induced autophagy to the development of anticancer drug resistance

Louis, USA

doi: 10.1016/bs.afnr.2021.02.010