As an E3 ubiquitin ligase, FBXO22 mediates the proteasomal degradation of multiple substrates
In parallel, it exhibits antiinflammatory actions by suppressing microglial activation and downregulating proinflammatory cytokines such as IL1 and TNF, attenuating the chronic neuroinflammation implicated in neuronal degeneration (Yang et al
Br J Clin Pharmacol 35:409412 Semis HS, Kandemir FM, Kaynar O, Dogan T, Arikan SM (2021) The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats
The benzyl alcohol works by slowing bacterial growth rather than killing bacteria outright, which makes it suitable for repeated use as long as proper aseptic techniques are followed
The small sample size of the control group due to our unequal randomization resulted in wide variability in the control group, ultimately limiting our ability to assess for true causal relationships by adequately testing for between-group differences