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When to extend time at a dose level The phase 2 trial protocols allowed participants to remain at their current dose for an extra two to four weeks before increasing if they experienced significant nausea
These changes may be partly neurological, as GLP-1 receptors in the brain's reward centres could modify how pleasurable certain foods feel
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Emerging clinical data from retatrutide and survodutide suggest that this strategy may be viable, though long-term safety, durability, and comparative effectiveness remain under active investigation
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