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In a clinical trial, people who took semaglutide lost an average of 15% of their body weight over a period of 68 weeks

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Studies in the pig showed GLP-1 inhibited pancreatic secretion induced by hypoglycemia (central neural stimulation) but not that due to vagal nerve stimulation (126)

Check the NIHR 'Be Part of Research' website or university hospital websites for opportunities, though availability is unpredictable