They contain herbal supplements, not GLP-1 medication, and the transdermal delivery method has not been shown to effectively absorb these ingredients in amounts that would influence appetite or metabolism
Regulatory approval poses another hurdle, as MNs must be evaluated as drug-device combinations, often extending approval timelines [108,109,110,111,112,113,]

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Ischemia-reperfusion injury (IRI) represents another significant challenge in critically ill and trauma patients