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Anxiety-like behavior In mice, supplementing the diet with a high N-6/N-3 PUFA ratio (from breeding until P14) led to increased prenatal stress (PRS)-induced anxiety-like behavior in the elevated plus maze (EPM) at two months of age [44]

Compounds absorbed here enter systemic circulation without passing through the hepatic portal system

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Skin-specific adverse effects were not highlighted as a primary safety signal in that publication, though injection site reactions were noted as expected with subcutaneous administration

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