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doi:10.1016/j.freeradbiomed.2008.09.013 Lee BH, Hsu WH, Chang YY, Kuo HF, Hsu YW, Pan TM (2012) Ankaflavin: a natural novel PPARgamma agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo

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However, studies show this increase typically brings IGF-1 levels into a normal, healthy physiological range, not a supraphysiological one

( Dibenzocyclooctadiene Lignans Schisandra chinensis (Turcz.) Baill (Schisandraceae), a widely used Chinese astringent botanical drug with the capability of invigorating the Qi of the five visceral organs, has been shown to produce therapeutic effects in various renal diseases ( Schisandra chinensis (Turcz.) Baill (Schisandraceae