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Response: We appreciate the feedback on additional measures and elements to improve the quality of care for heart failure patients, such as those focused on early screening and diagnosis of CRM conditions, palliative care, CAHPS patient experience measures, depression screening, novel medical therapies, and composite guideline-directed medical therapy (GDMT)

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Its possible that, in addition to lipid peroxidation and PS exposure, apoptotic or necroptotic stimuli are causing detrimental effects that are not triggered by GPX inhibition

The vast part of this evidence arises from preclinical animal studies or cell cultures