To evaluate the convergence of published results, we first conduct a multi-level kernel density meta-analysis of studies reporting a positive association of ghrelin ( N comb = 353, 18 contrasts) and a negative association of GLP-1 ( N comb = 258, 12 contrasts) and reward responses measured using task functional magnetic resonance imaging (fMRI)
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Check with your doctor immediately if any of the following side effects occur while taking tirzepatide: More common side effects stomach pain Less common side effects difficulty in breathing or swallowing fast heartbeat gaseous stomach pain heartburn recurrent fever skin itching, rash, or redness stomach fullness swelling of the face, throat, or tongue vomiting yellow eyes or skin Incidence not known anxiety bloating blurred vision change in vision changes in behavior chest tightness chills cold sweats coma confusion constipation cool, pale skin cough darkened urine depression dizziness fast heartbeat fever increased hunger indigestion large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of appetite nausea nervousness nightmares pains in the stomach, side, or abdomen, possibly radiating to the back puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue seizures shakiness slurred speech thoughts of harming oneself unusual tiredness or weakness Other side effects of tirzepatide Some side effects of tirzepatide may occur that usually do not need medical attention
Mild to moderate stomach pain is common and often manageable with dietary modifications, but severe persistent pain, signs of pancreatitis, or symptoms of gallbladder disease require immediate medical assessment and may necessitate treatment discontinuation
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