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As expected, following the same immunoprecipitation approach as above, we measured a complete loss of serine phosphorylation in response to GLP-1 stimulation in the triple AA mutant compared to the WT receptor (Fig

Pathohistological analysis After sacrificing the respective tissue was dissected, fixed in buffered formalin (pH 7.4) for 24 hours and embedded in paraffin using standard procedures

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Research Applications: Two Peptides, Two Different Worlds This fundamental difference in mechanism naturally leads to vastly different applications in a research setting

The peptides mechanism involves binding to the growth hormone secretagogue receptor (GHS-R), which activates signaling pathways that prompt the pituitary gland to secrete growth hormone