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Mechanism of Action PT-141 exerts its pro-sexual effects primarily through agonist activity at melanocortin receptors, particularly MC3R and MC4R, which are G-protein coupled receptors expressed in key brain regions regulating sexual function, motivation, and reward

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The fluorescence of TRFS-Green is induced by the TGR (or TrxR)-mediated disulfide cleavage followed by intramolecular cyclization to liberate the masked naphthalimide fluorophore