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Acetyl-L-carnitine attenuates arsenic-induced oxidative stress and hippocampal mitochondrial dysfunction

The study was conducted in accordance with the protocol and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Good Clinical Practice guidelines, Declaration of Helsinki and applicable Swiss and European Union regulations

Furthermore, impaired communication between the ER and mitochondria-especially through mitochondria-associated membranes (MAMs)-appears to exacerbate these stress responses, reinforcing the interplay between calcium dysregulation, redox imbalance, and cell death

Hypertension 69 , 10361044 (2017)