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Figure 3: Changes in the lameness period amongst the four experimental treatment groups

In some cases, it can reduce healing time by 30-50%

The figure shows a gradual chain: intervention, flora changes, metabolite transformation, immune/inflammatory pathway readings, which eventually lead to the phytotype of rheumatoid arthritis

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41 In detail, the elevated extracellular ATP induced by SD stress stimulates P2 7 R and down-regulates the expression of 5-HT 2B R by suppressing the activation of AKT, which inhibits the phosphorylation of FoxO3a and promotes its transportation into the nucleus, the reduced 5-HT 2B R alleviates the inhibition of STAT3 to cPLA 2 , the activated cPLA 2 further increases the release of AA and PGE2, these indicators have high relationship with the depressive-like behaviors, because in P2X 7 R knockout mice, the above changes of these indicators and behavioral performance are all eliminated