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A 2016 clinical trial by Zubair et al

Decrease your serving sizes

However, their persistence in the environment raises serious toxicological concerns, such as lung toxicity (inflammation, fibrosis, and respiratory dysfunction), skin toxicity (allergic reactions and dermatitis), liver damage (oxidative stress and lipid peroxidation), kidney toxicity (nephrotoxicity and filtration interference), and cardiovascular problems (endothelial dysfunction and arterial plaque formation)

3HSD2 is also responsible for the conversion of E2 into E1