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By kinetic analysis of single, double, and triple mutants, as well as from studies of reaction products, it was established that the enzyme A216H catalyzes the hydrolysis of the thiol-ester substrate by a mechanism that includes an acyl intermediate at the side chain of Y9

Catalpol also demonstrates neuroprotection in Alzheimers disease (Tian et al., 2025)

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Some studies describe occasional localized redness or mild irritation during topical research applications, while systemic toxicity has not been observed at commonly investigated research concentrations

Murphy TH, Schnaar RL, Coyle JT