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KPV's anti-inflammatory mechanism through NF-B pathway inhibition and mast cell stabilization works regardless of timing, but practical considerations influence optimal scheduling - oral/sublingual KPV requires empty stomach for absorption (morning before eating or night before bed most practical), subcutaneous injection timing flexibility allows either morning or evening based on routine and side effect patterns, and transdermal application can occur anytime but consistency matters more than specific hour

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[DOI] [PubMed] [Google Scholar] Salehpour et al

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