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The side effects were most commonly gastrointestinal disturbances such as nausea and vomiting and occurred in a similar frequency to those reported with dual receptor co-agonists [61]

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Lichtenwalner et al., reported that altered levels of IGF-1 negatively affect neurogenesis and synaptic plasticity, particularly in the hippocampus [36]

Subsequently, the design of CAR has undergone continuous evolution and refinement ( Figure 1 ) ( in vivo expansion and persistence, impeding a durable anti-tumor response

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