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When children remain refractory to acute or prophylactic treatment, or the episode differs from previous ones, the clinician should consider the possibility of an underlying disease and further mono- or combination therapy and psychotherapy can be guided by accompanying comorbidities and specific sub-phenotype

Hum Mutat 21:493501 Ohtani Y, Tomoda A, Miike T, Matsukura M, Miyatake M et al (1994) Central nervous system disorders and possible brain type carnitine palmitoyltransferase II deficiency

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Curr Neuropharmacol (2016) 14:72131