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Additionally, they indicated that under these conditions PBMCs express elevated levels of IFN-, IL-1, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), TNF-, RANTES/CCL5 (Regulated on Activation, Normal T cell Expressed and Secreted), and macrophage inflammatory protein (MIP)-1 (125)

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The connective tissues need to adapt to new loading patterns while simultaneously dealing with reduced systemic inflammation and altered hormonal profiles