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Also, the interaction with stromal cells increases the glycolytic flux of AML cells from patients through the CXCR4/CXCL12/mTOR axis (Braun et al., 2016), and the use of selective inhibitors of this axis represents an opportunity to block MSC-mediated chemoresistance (Braun et al., 2016)

First, we verified that in the plasma of female mice with fibrosarcoma invasion, a typical example of NRTP, CXCL10 was the primary pro-inflammatory cytokine that is detrimental to the ovaries

Their combined use could redefine treatment paradigms for diseases where traditional therapies fall short