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b Estimated using an ANCOVA based on data irrespectively of discontinuation of trial product or initiation of rescue medication adjusted for baseline value, background medication and region

The two compounds work through entirely independent systems

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Animals were maintained in individually ventilated cages at 22 C at 80% humidity at a density of up to 5 per cage, with ad libitum access to food and water

Conversely, the Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial (REDUCEIT), which included over 50% of participants with diabetes, demonstrated that daily supplementation with 4 g of icosapent ethyl (a highly purified and stable eicosapentaenoic acid ethyl ester) significantly reduced cardiovascular risk [336]