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This potential tolerogenicity is based on the observation that any impurity peptide containing modifications in this region that changed the TCR face resulted in an increase in the number of donor PBMC samples that responded to the peptide, and increased the magnitude of the IFN- response as well

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"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system." Journal of Pharmacology and Experimental Therapeutics