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In the context of GH and IGF-I physiology it can be concluded that 1) during childhood and adolescence the combined actions of GH and IGF-I in the presence of sufficient nutrition promote longitudinal growth and somatic maturation, 2) continued excess IGF-I activity in adulthood increases the risk for cardiovascular and neoplastic diseases and hence reduces longevity, 3) calorie restriction, which suppresses IGF-I activity and stimulates GH secretion, may promote longevity in human adults (82)

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Clinical evidences on the DPP-4 inhibitor sitagliptin suggests it is associated with a decreased risk of prostate cancer [106, 110], and long-term administration of this agent may have potential benefits for breast cancer [96]