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We specifically focused on behavioral outcomes, which highlights the functional significance of the findings

To further verify that the catalytic activity of LOXL2 was responsible for the increase in BHZ signal, we used the following negative controls: (1) the overexpression of catalytically inactive H626/628Q LOXL2 double mutant (LOXL2-DM) 39,40 , (2) inhibition of LOXL2 specific activity using the small molecule inhibitor PAT-1251 (10 M) in cells overexpressing catalytically active LOXL2 41 , and (3) inhibition of total LOX activity using the non-selective small molecule LOX inhibitor -Aminopropionitrile (BAPN

Enbrel (etanercept) is a medication that is prescribed to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis

doi: 10.1038/bjc.2013.438 308 LeeSJJeongJ-HLeeIHLeeJJungJHParkHYet al

The Lancet , 398 (10295), 143-155