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H2-receptor antagonists (like famotidine) or proton pump inhibitors (PPIs such as omeprazole or esomeprazole) offer more sustained acid suppression for frequent or severe symptoms

SURMOUNT-5 was a 72-week, multi-centre, randomised, open-label, Phase 3b trial evaluating the efficacy and safety of tirzepatide compared with semaglutide in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidaemia, obstructive sleep apnoea (OSA) or cardiovascular disease, who did not have diabetes

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10.1016/J.CMET.2016.07.015 168